期刊
TALANTA
卷 219, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.talanta.2020.121185
关键词
Microextraction by packed sorbent (MEPS); Molecularly imprinted polymer (MIP); Cannabinoids; Automated microextraction; Tandem mass spectrometry; Urine
资金
- Sao Paulo Research Foundation (FAPESP) [2010/19910-9, 2014/03795-0, 2017/02147-0, 2019/22724-7]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [311300/2015-4, 130802/2016-6, 312212/2018-6]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [001]
An original, selective and automated method, for the microextraction by packed sorbent (MEPS) of Delta 9-tetrahydrocannabinol (THC), 11-hydroxy-Delta 9-tetrahydrocannabinol (THC-OH), and 11-nor-Delta 9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) from human urine, was developed by using (i) a catechin-molded molecularly imprinted polymer (MIP), (ii) a new lab-made MEPS device easily repackable with any commercial or lab-made sorbent, and (iii) a lab-made multi syringe autosampler. Analyses were performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and the developed method proved to be precise, accurate and showed good linearity. Determination coefficients ranged from 0.96 to 0.99, in the range of 5-250 ng mL(-1). Limits of detection and quantification ranged between 1.0 and 5.0 ng mL(-1) and 5.0 and 20.0 ng mL(-1). The method was successfully applied in the analysis of real urine samples. The same packed syringe was effectively used over 90 consecutive extractions without carry-over effects.
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