期刊
SYNLETT
卷 31, 期 10, 页码 977-981出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1708007
关键词
aldoximes; 2-cyanoglycals; nitriles
资金
- South African Agency for Science and Technology Advancement [NRF 118552]
Glycals, 1,2-unsatrated carbohydrates, are versatile building blocks for the synthesis of various scaffolds. Despite their potential to serve as suitable precursors in diversity-oriented synthesis, 2-cyanoglycals are less explored in terms of their synthesis and derivatization. Herein, we report a combination of Ac2O and AcOH as new and efficient dehydrating agent of aldoximes for the synthesis of 2-cyanoglycals. In comparison to the conventional dehydrating system of Ac2O-base (such as NaOH, NaOAc and K2CO3), the current protocol provides superior yields and faster reaction rates. The scope and limitations of the dehydrating system are investigated.
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