期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 311, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2020.127863
关键词
Hierarchical nanostructures; Electrochemical biosensor; Mo2C@MoS2; H2O2 sensing; Cancer-cell detection
资金
- National Natural Science Foundation of China [21773093]
- Guangdong Natural Science Funds for Distinguished Young Scholar [2015A030306014]
- Guangzhou Science and Technology Program [201707010268]
Heterostructures hierarchically integrating various building blocks are promising to construct sensitive and versatile biosensing platforms. Herein, hierarchical Mo2C@MoS2 consisting of interlayer-expanded MoS2 nanosheets wrapping on Mo2C nanorods is developed as a sensitive and bifunctional electrochemical platform to detect cellular metabolism products (e.g., H2O2) and cancer cells. Utilizing the merits of one-dimensional Mo2C axis (e.g., high conductivity) and two-dimensional MoS2 nanosheets (e.g., enhanced *OH binding, highly exposed edge-sites, and tolerance against oxidative H2O2), the Mo2C@MoS2 afford a high sensitivity (1080 mu A mM(-1) cm(-2)) and a low detection limit (0.2 mu M) for H2O2 sensing, superior to the most of materials free from enzymes and noble metals. Its outstanding tolerance to various interferents ensures the practical monitoring of the intracellular H2O2 amount in MDA-MB-231, a human breast cancer cell line, which provides an indirect but available detection of tumor cells. As a versatile sensing platform, moreover the Mo2C@MoS2 with rich surface amino groups performs well to directly and specifically detect MDA-MB-231 after immobilizing folic acid. This work is anticipated to open up new opportunities toward high-performance sensing materials via surface/interfacial engineering on heterostructures.
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