期刊
SCIENCE CHINA-CHEMISTRY
卷 63, 期 4, 页码 454-459出版社
SCIENCE PRESS
DOI: 10.1007/s11426-019-9687-1
关键词
asymmetric catalysis; palladium; allylic C-H alkylation; 1; 4-diene; glycine Schiff base
资金
- Ministry of Science and Technology of China [2015CB856600]
- National Natural Science Foundation of China [21672197, 21602214]
- Chinese Academy of Sciences [XDB20020000]
A highly regio- and enantioselective allylic C-H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate a wide scope of 1,4-dienes, delivering structurally diverse chiral beta-branched a-amino acid surrogates in moderate to high yields and with high levels of regio-, Z/E-, diastereo- and enantioselectivities.
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