Palladium-catalyzed asymmetric allylic C-H alkylation of 1,4-dienes and glycine Schiff bases

A highly regio- and enantioselective allylic C-H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate a wide scope of 1,4-dienes, delivering structurally diverse chiral beta-branched a-amino acid surrogates in moderate to high yields and with high levels of regio-, Z/E-, diastereo- and enantioselectivities.