期刊
SCIENCE
卷 369, 期 6501, 页码 330-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abb9983
关键词
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资金
- International AIDS Vaccine Initiative
- Bill and Melinda Gates Foundation through the Collaboration for AIDS Vaccine Discovery [OPP1084519, 1196345]
- NIAID [R01-AI127521]
- Scripps Consortium for HIV Vaccine Development (CHAVD) [AI144462]
The emergence of the betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus 2019 (COVID-19), represents a considerable threat to global human health. Vaccine development is focused on the principal target of the humoral immune response, the spike (S) glycoprotein, which mediates cell entry and membrane fusion. The SARS-CoV-2 S gene encodes 22 N-linked glycan sequons per protomer, which likely play a role in protein folding and immune evasion. Here, using a site-specific mass spectrometric approach, we reveal the glycan structures on a recombinant SARS-CoV-2 S immunogen. This analysis enables mapping of the glycan-processing states across the trimeric viral spike. We show how SARS-CoV-2 S glycans differ from typical host glycan processing, which may have implications in viral pathobiology and vaccine design.
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