期刊
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
卷 52, 期 12, 页码 1017-1024出版社
SPRINGER
DOI: 10.1007/s10593-017-2002-3
关键词
coumarins; quinazolin-4(3H)-one; anti-lipase activity; alpha-glucosidase inhibition; microwave; ultrasonication
资金
- Scientific and Technological Research Council of Turkey (TUBITAK) [115Z885]
- TUBITAK
A new series of 2-substituted quinazolin-4(3H)-one derivatives including coumarin nucleus has been synthesized and screened for their lipase and a-glucosidase inhibition properties. Among the synthesized compounds, N'-{2-[2-(3,4-dichlorobenzyl)-4-oxoquinazolin-3(4H)-yl]acetyl}-2-oxo-2H-chromene-3-carbohydrazide and N'-{2-[2-(4-bromobenzyl)-4-oxoquinazolin-3(4H)-yl] acetyl}-2-oxo-2H-chromene-3-carbohydrazide showed the best inhibitory effect against a-glucosidase with IC50 values of 6.11 +/- 0.40 and 7.34 +/- 0.37 mu M, respectively. These compounds also showed strong anti-lipase activity (IC50 3.52 +/- 0.49 and 2.85 +/- 0.27 mu M, respectively).
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