期刊
CHEMISTRY LETTERS
卷 45, 期 11, 页码 1259-1261出版社
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.160687
关键词
CO2 reduction; Viologen derivative; Artificial coenzyme
资金
- Precursory Research for Embryonic Science and Technology (PRESTO, Japan Science and Technology Agency JST)
- [15K14239]
- [2406]
- Grants-in-Aid for Scientific Research [24107005, 15K14239] Funding Source: KAKEN
Formate dehydrogenase (FDH) is an attractive biocatalyst for CO2 reduction. The reduced form of methylviologen acts as an artificial coenzyme for FDH. For further improvement in the CO2 reduction catalytic activity of FDH, a viologen derivative with two amino groups, 1,1'-diaminoethyl-4,4'-bipyridinium salt (DA(2+)), was synthesized as the effective artificial coenzyme for FDH. By enzyme kinetic analysis, the catalytic efficiency, i.e., k(cat)/K-m value of the reduced form of DA(2+) was estimated to be more than 560 times larger than that of NADH, the natural coenzyme for FDH.
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