期刊
REGENERATIVE MEDICINE
卷 15, 期 3, 页码 1463-1491出版社
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2019-0145
关键词
cell therapy; cell therapy safety; cryobiology; cryopreservation; cryoprotectants; cryoprotectant toxicity; dimethyl sulfoxide; DMSO toxicity
Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its effectiveness. It will also consider means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据