期刊
PSYCHOLOGICAL MEDICINE
卷 51, 期 12, 页码 2094-2103出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291720000860
关键词
Anxiety; depression; inflammation; insomnia; sleep; suicide
资金
- Geestkracht program of the Netherlands Organization for Health Research and Development (ZonMW) [10-000-1002]
- VU University Medical Center
- GGZ inGeest
- Leiden University Medical Center
- Leiden University
- GGZ Rivierduinen
- University Medical Center Groningen
- University of Groningen
- Lentis
- GGZFriesland
- GGZ Drenthe
- Rob Giel Onderzoekcentrum
This study showed that both short and long sleep duration, insomnia symptoms, and IL-6 are associated with suicide risk indicators, with the association between long sleep duration and suicidal ideation possibly mediated by IL-6.
Background Sleep disturbance has been consistently identified as an independent contributor to suicide risk. Inflammation has emerged as a potential mechanism linked to both sleep disturbance and suicide risk. This study tested associations between sleep duration, insomnia, and inflammation on suicidal ideation (SI) and history of a suicide attempt (SA). Methods Participants included 2329 adults with current or remitted depression and/or anxiety enrolled in the Netherlands Study of Depression and Anxiety. Sleep duration, insomnia, past week SI, and SA were assessed with self-report measures. Plasma levels of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha were obtained. Results Short sleep duration (<= 6 h) compared to normal sleep duration (7-9 h) was associated with reporting a prior SA, adjusting for covariates [adjusted odds ratio (AOR) 1.68, 95% CI 1.13-2.51]. A higher likelihood of SI during the past week was observed for participants with long sleep duration (> 10 h) compared to normal sleep duration (AOR 2.22, 95% CI 1.02-4.82), more insomnia symptoms (AOR 1.44, 95% CI 1.14-1.83), and higher IL-6 (AOR 1.31, 95% CI 1.02-1.68). Mediation analyses indicated that the association between long sleep duration and SI was partially explained by IL-6 (AOR 1.02, 95% CI 1.00-1.05). Conclusions These findings from a large sample of adults with depression and/or anxiety provide evidence that both short and long sleep duration, insomnia symptoms, and IL-6 are associated with the indicators of suicide risk. Furthermore, the association between long sleep duration and SI may operate through IL-6.
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