期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 199, 期 -, 页码 17-25出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2016.04.001
关键词
Cholesterol; Sterol; Membrane dynamics; Membrane structure; Lipid domains
资金
- VEGA grant [1/0916/16]
- collaborative SR-JINR program [04-4-1121-2015/2017]
- Scientific User Facilities Division of the DOE Office of Basic Energy Sciences under US DOE [DE-AC05-00OR22725]
It is well known that cholesterol modifies the physical properties of lipid bilayers. For example, the much studied liquid-ordered L-0 phase contains rapidly diffusing lipids with their acyl chains in the all trans configuration, similar to gel phase bilayers. Moreover, the L-0 phase is commonly associated with cholesterol-enriched lipid rafts, which are thought to serve as platforms for signaling proteins in the plasma membrane. Cholesterol's location in lipid bilayers has been studied extensively, and it has been shown - at least in some bilayers - to align differently from its canonical upright orientation, where its hydroxyl group is in the vicinity of the lipid-water interface. In this article we review recent works describing cholesterol's location in different model membrane systems with emphasis on results obtained from scattering, spectroscopic and molecular dynamics studies. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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