期刊
CHEMISTRY & BIODIVERSITY
卷 14, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201600184
关键词
Penicillium expansum; Expansolides C and D; -Glucosidase inhibitory activities; Bergamotane; Sesquiterpenes
资金
- National Natural Science Foundation of China [21402174]
- Natural Science Foundation of Zhejiang Province [LY15H280003]
- Key Project of Chinese Medicine in Zhejiang Province [2015ZZ001]
- Traditional Chinese Medicine and Outstanding Young Talent Scientific Foundation of Zhejiang Province [2014ZQ005]
- Zhejiang Xinmiao Talent Projects [2015R403044]
- Zhejiang Provincial Top Key Discipline of Biology
- Open Foundation [2015D16]
Two new bergamotane sesquiterpene lactones, named expansolides C and D (1 and 2), together with two known compounds expansolides A and B (3 and 4), were isolated from the plant pathogenic fungus Penicillium expansum ACCC37275. The structures of the new compounds were established by detailed analyses of the spectroscopic data, especially 1D-, 2D-NMR, and HR-ESI-MS. In an in vitro bioassay, the epimeric mixture of expansolides C and D (1 and 2) (in a ratio of 2:1 at the temprature of the bioassay) exhibited more potent -glucosidase inhibitory activity (IC50 =0.50 +/- 0.02 mm) as compared with the positive control acarbose (IC50 = 1.90 +/- 0.05 mm). To the best of our knowledge, it was the first report on the -glucosidase inhibitory activity of bergamotane sesquiterpenes.
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