4.7 Article

LIF or dye: Comparison of different tracing methods for granular solids

期刊

POWDER TECHNOLOGY
卷 367, 期 -, 页码 20-31

出版社

ELSEVIER
DOI: 10.1016/j.powtec.2020.03.033

关键词

Capsule filling; Residence time distribution; Pmcess analytical technology; Tracer; Fluorescence; Powder technology

资金

  1. Austrian COMET Program under the Austrian Federal Ministry of Transport, Innovation and Technology (bmvit)
  2. Austrian Federal Ministry of Economy, Family and Youth (bmwfj), Austria
  3. State of Styria (Styrian Funding Agency SFG)
  4. BOSCH Packaging

向作者/读者索取更多资源

Determination of residence time distribution is considered essential for continuous pharmaceutical unit operations, in order to enable process understanding and control. A common way for determining residence times are tracer based methods, yet at the moment most realizations are found in liquid systems whereas use of those methods on granular samples is rarely encountered. Here, we compare two different methods for applying and detecting tracers in granular material processed in a pharmaceutical capsule-filling unit. As first method, a simple colorimetric procedure, i.e. using a dye and a camera as photometer is used. As second method, light induced fluorescence, i.e. using a fluorescent tracer material, a stimulating source and the camera as photometer again, is used. Both methods are tested and compared for their performance and appeared to be sufficient for the use in residence time distribution determination, yet none of the two proved to be superior. Consequently, side issues rather than analytic performance determined the final preference for the colorimetric method. (C) 2020 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据