期刊
POLYMER
卷 196, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2020.122462
关键词
Topography; PDA coating; Long-term stability; Osteogenic differentiation; Poly(L-lactic acid)
资金
- National Natural Science Foundation of China [81701109, 51803139, 21776186]
Nanotopographical and chemical cues were collectively introduced onto the poly(L-lactic acid) (PLLA) surface via alkali etching and polydopamine (PDA) coating. The surface pattern was made of dense-packed PLLA lamellae, and the PDA coating did not change the feature of surface topography. Both nanotopographical pattern and PDA coating showed long-term stability in cell culture medium for two weeks. In vitro evaluations displayed that there was a synergy between nanotopography and PDA coating on cell adhesion, proliferation, and differentiation of osteoblasts, even for a culture period of two weeks. This sustained effect was attributed to the activation of the wnt/beta-catenin pathway. These results hold a promising prospect for the application of bone repair grafts.
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