The First Effort for the Preparation of Amidoalkyl Naphthoquinone Skeleton Based on Solvent-Free Multicomponent Reaction

For the first time, medicinally substantial amidoalkyl naphthoquinones are prepared via an eco-friendly, appropriate, and straightforward protocol accomplishing through the one-pot multicomponent reaction of aromatic aldehyde, 2-hydroxy-1,4-naphthoquinone (lawsone) and benzamide or acetamide at 80 degrees C under solvent-free condition in presence of p-TSA as a catalyst. It is awaited that our methodology to be effective in the combinatorial synthesis of bioactive compounds; because amidoalkyl naphthoquinone derivatives are a very important category of naturally occurring compounds. The structures of synthesized compounds were characterized by H-1, C-13 NMR, mass spectroscopy and elemental analysis.

Automated summary

In this study, medicinally important amidoalkyl naphthoquinones were synthesized via an eco-friendly and straightforward method. The one-pot multicomponent reaction successfully prepared the precursors of these natural compounds, which are of great significance in medicinal research. The synthesized compounds were characterized using various techniques.