期刊
PHYTOCHEMISTRY LETTERS
卷 36, 期 -, 页码 49-57出版社
ELSEVIER
DOI: 10.1016/j.phytol.2020.01.015
关键词
Caralluma hexagona; Asclepiadaceae; Pregnane glycosides; alpha-glucosidase; Lipase
资金
- Academy of Scientific Research and Technology under the Egypt Research and Technology Alliances (EG-KTA) Program [KTA-C2-2.10]
Three new pregnane glycosides in addition to four known compounds were isolated from the methylene chloride fraction of Caralluma hexagona Lavranos using bioassay-guided fractionation. The new compounds were identified as 12,20-di-O-benzoyl-3 beta,8 beta,12 beta,14 beta,20-pentahydroxy-(20R)-pregn-5-ene-3-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-digitaloside (1), 3 beta,8 beta,14 beta,20-tetrahydroxy (20R)-pregn-5-ene-3-O-beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-digitaloside-20-O-beta-D-glucopyranoside (2), 3 beta,8 beta,14 beta,20-tetrahydroxy-(20R)-pregn-5-ene-3-O-beta-D-glucopyranosyl(1 -> 6)-O-beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-digitaloside-20-O-beta-D-glucopyranoside (3), along with the known compounds luteolin 4'-O-neohesperidoside (4), apigenin-8-C-neohesperoside (5), beta-sitosterol (6) and beta-sitosterol glucoside (7). Preliminary studies of the crude methanolic extract and methylene chloride fraction showed inhibitory effects against alpha-glucosidase and pancreatic lipase. Among the isolated compounds, compound 5 showed the most potent alpha-glucosidase inhibition with IC50 value of 0.82 +/- 2.50 mu M compared to acarbose (0.81 +/- 0.86 mu M). Whereas compound 1 showed the highest inhibitory activity on pancreatic lipase with an IC50 value of 23.59 +/- 2.49 mu M compared to orlistat (7.41 +/- 2.26 mu M).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据