期刊
PHYTOCHEMISTRY
卷 172, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2020.112275
关键词
Streptomyces; Actinomycetes; Sulfur-containing compound; Abyssomicins; Antibacterial; Antitubercular
资金
- Thailand Research Fund (TRF) [RSA6280019]
- National Center for Genetic Engineering and Biotechnology (BIOTEC grant) [P19-50917]
- Actinobacterial Research Unit (ARU) at King Mongkut's Institute of Technology Ladkrabang [2562-01-05-47]
- Faculty of Science at King Mongkut's Institute of Technology Ladkrabang [2562-01-05-47]
Eight previously undescribed naturally-occurring compounds, including abyssomycins Y - Z, methyl aeruginoate, desferri-ferrithocin-4-hydroxyphenethylester, streptomethiocins A - B, furaquinocin I, and streptolactone, along with eleven known compounds were isolated from the endophytic Streptomyces sp. TBRC7642. The chemical structures were determined based on spectroscopic means including 1D, 2D NMR spectroscopy and mass spectrometry. The absolute configurations were assigned by relying on CD spectra and their optical rotations. In addition, the isolated compounds were evaluated for biological activity, such as antimalarial, antitubercular, antibacterial (both Gram-positive and Gram-negative bacteria), as well as for cytotoxicity against MCF-7, NCI-H187, and Vero cells.
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