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Berna C. Oezdemir et al.
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Andrew D. Rhim et al.
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Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Martin Augsten et al.
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The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy
Ruth Scherz-Shouval et al.
CELL (2014)
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
Mara H. Sherman et al.
CELL (2014)
Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer
Natalie Hartmann et al.
CLINICAL CANCER RESEARCH (2014)
Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
Edward J. Kim et al.
CLINICAL CANCER RESEARCH (2014)
The extracellular matrix modulates the hallmarks of cancer
Michael W. Pickup et al.
EMBO REPORTS (2014)
The Transcription Factor GLI1 Modulates the Inflammatory Response during Pancreatic Tissue Remodeling
Esha Mathew et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Fibroblast heterogeneity in the cancer wound
Daniel Oehlund et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
Cole Trapnell et al.
NATURE BIOTECHNOLOGY (2014)
Remodelling the extracellular matrix in development and disease
Caroline Bonnans et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
Talmadge E. King et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis
Luca Richeldi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression
G. Comito et al.
ONCOGENE (2014)
Inhibition of tumor cell proliferation and motility by fibroblasts is both contact and soluble factor dependent
Twana Alkasalias et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
John J. Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Anoop P. Patel et al.
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Sabine A. Eming et al.
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Prognostic relevance of cancer-associated fibroblasts in human cancer
Janna Paulsson et al.
SEMINARS IN CANCER BIOLOGY (2014)
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling
Wan-Jiun Chen et al.
NATURE COMMUNICATIONS (2014)
Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling
Esha Mathew et al.
CELL REPORTS (2014)
The role of DNA damage and repair in aging through the prism of Koch-like criteria
Alexey A. Moskalev et al.
AGEING RESEARCH REVIEWS (2013)
Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells
Shingo Kozono et al.
CANCER RESEARCH (2013)
Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance
Yaqing Zhang et al.
CANCER RESEARCH (2013)
Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Ludivine Bochet et al.
CANCER RESEARCH (2013)
Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma
Xiang H. -F. Zhang et al.
CELL (2013)
A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response
Ning Ding et al.
CELL (2013)
Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation
Maria Ester Bernardo et al.
CELL STEM CELL (2013)
Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
Abasi Ene-Obong et al.
GASTROENTEROLOGY (2013)
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
Michael A. Jacobetz et al.
GUT (2013)
Hepatic stellate cells in liver development, regeneration, and cancer
Chunyue Yin et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
Edward W. Roberts et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
Carcinoma-associated fibroblasts derive from mesothelial cells via mesothelial-to-mesenchymal transition in peritoneal metastasis
Pilar Sandoval et al.
JOURNAL OF PATHOLOGY (2013)
Distinct fibroblast lineages determine dermal architecture in skin development and repair
Ryan R. Driskell et al.
NATURE (2013)
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
Fernando Calvo et al.
NATURE CELL BIOLOGY (2013)
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
Dereck Amakye et al.
NATURE MEDICINE (2013)
CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer
Albrecht Neesse et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury
Yuchang Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
Christine Feig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
Vikash P. Chauhan et al.
NATURE COMMUNICATIONS (2013)
Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis
Younghun Jung et al.
NATURE COMMUNICATIONS (2013)
Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
Ingmar Mederacke et al.
NATURE COMMUNICATIONS (2013)
Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
Alexandre Calon et al.
CANCER CELL (2012)
Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
Paolo P. Provenzano et al.
CANCER CELL (2012)
Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression
Ermira Pazolli et al.
CANCER RESEARCH (2012)
Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non-Small Cell Lung Cancer In Vivo
Silvestre Vicent et al.
CANCER RESEARCH (2012)
Extracellular matrix players in metastatic niches
Thordur Oskarsson et al.
EMBO JOURNAL (2012)
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
Helene Salmon et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Comprehensive care and care at the center of the new recommendation HAS
Elisa Derrien
ACTUALITES PHARMACEUTIQUES (2012)
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
Ravid Straussman et al.
NATURE (2012)
Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature
Yuval Rinkevich et al.
NATURE CELL BIOLOGY (2012)
Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury
Sophie Dulauroy et al.
NATURE MEDICINE (2012)
Origins of the Tumor Microenvironment: Quantitative Assessment of Adipose-Derived and Bone Marrow-Derived Stroma
Shannon Kidd et al.
PLOS ONE (2012)
Dextran Sodium Sulfate (DSS) Induces Colitis in Mice by Forming Nano-Lipocomplexes with Medium-Chain-Length Fatty Acids in the Colon
Hamed Laroui et al.
PLOS ONE (2012)
Involvement of Host Stroma Cells and Tissue Fibrosis in Pancreatic Tumor Development in Transgenic Mice
Itai Spector et al.
PLOS ONE (2012)
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
Triantafyllos Stylianopoulos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
Tatiana Kisseleva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer
Anirban K. Mitra et al.
CANCER DISCOVERY (2012)
CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues
Rosa Anna DeFilippis et al.
CANCER DISCOVERY (2012)
Interactions between cancer stem cells and their niche govern metastatic colonization
Ilaria Malanchi et al.
NATURE (2012)
Animal models for arthritis: innovative tools for prevention and treatment
George Kollias et al.
ANNALS OF THE RHEUMATIC DISEASES (2011)
Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence
Carmen Guerra et al.
CANCER CELL (2011)
Deletion of p120-Catenin Results in a Tumor Microenvironment with Inflammation and Cancer that Establishes It as a Tumor Suppressor Gene
Douglas B. Stairs et al.
CANCER CELL (2011)
Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
Michael Quante et al.
CANCER CELL (2011)
Pancreatic Stellate Cells Radioprotect Pancreatic Cancer Cells through β1-Integrin Signaling
Tine S. Mantoni et al.
CANCER RESEARCH (2011)
Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis
Jacky G. Goetz et al.
CELL (2011)
Targeting Galectin-1 in Carcinoma-Associated Fibroblasts Inhibits Oral Squamous Cell Carcinoma Metastasis by Downregulating MCP-1/CCL2 Expression
Ming-Heng Wu et al.
CLINICAL CANCER RESEARCH (2011)
Retinoic Acid-Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt-β-Catenin Signaling to Slow Tumor Progression
Fieke E. M. Froeling et al.
GASTROENTEROLOGY (2011)
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
Yuchen Chien et al.
GENES & DEVELOPMENT (2011)
Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation
Ilona Gutcher et al.
IMMUNITY (2011)
Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
Kan Cao et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
Thordur Oskarsson et al.
NATURE MEDICINE (2011)
Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells
Weiwei Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors
Benjamin Diop-Frimpong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
Joyce T. O'Connell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
Jason R. Rock et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner
Neta Erez et al.
CANCER CELL (2010)
Breast Carcinoma-Associated Fibroblasts Rarely Contain p53 Mutations or Chromosomal Aberrations
Abdel Nasser Hosein et al.
CANCER RESEARCH (2010)
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
Ubaldo E. Martinez-Outschoorn et al.
CELL CYCLE (2010)
Oxidative stress promotes myofibroblast differentiation and tumour spreading
Aurore Toullec et al.
EMBO MOLECULAR MEDICINE (2010)
CD10+ Pancreatic Stellate Cells Enhance the Progression of Pancreatic Cancer
Naoki Ikenaga et al.
GASTROENTEROLOGY (2010)
CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model
Chang H. Lee et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals
Suzana Makpol et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2010)
Inhibition of Pancreatic Stellate Cell Activation by Halofuginone Prevents Pancreatic Xenograft Tumor Development
Itai Spector et al.
PANCREAS (2010)
Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers
Amel Saadi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion
Katharine D. Grugan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Malignant cells facilitate lung metastasis by bringing their own soil
Dan G. Duda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
Yasushi Kojima et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-α
Matthew Kraman et al.
SCIENCE (2010)
Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors
Edna Cukierman et al.
SEMINARS IN CANCER BIOLOGY (2010)
The polarization of immune cells in the tumour environment by TGFβ
Richard A. Flavell et al.
NATURE REVIEWS IMMUNOLOGY (2010)
Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts
Charlotte Anderberg et al.
CANCER RESEARCH (2009)
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Kandice R. Levental et al.
CELL (2009)
The reverse Warburg effect Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
Stephanos Pavlides et al.
CELL CYCLE (2009)
Stromal Matrix Protein Expression Following Preoperative Systemic Therapy in Breast Cancer
Anna-Maria Tokes et al.
CLINICAL CANCER RESEARCH (2009)
Pten in stromal fibroblasts suppresses mammary epithelial tumours
Anthony J. Trimboli et al.
NATURE (2009)
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
Akifumi Ootani et al.
NATURE MEDICINE (2009)
Inhibition of Transforming Growth Factor β Signaling by Halofuginone as a Modality for Pancreas Fibrosis Prevention
Orit Zion et al.
PANCREAS (2009)
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive et al.
SCIENCE (2009)
Senescence-messaging secretome: SMS-ing cellular stress
Thomas Kuilman et al.
NATURE REVIEWS CANCER (2009)
Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells
Pravin J. Mishra et al.
CANCER RESEARCH (2008)
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
Thomas Kuilman et al.
CELL (2008)
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
Wen Qiu et al.
NATURE GENETICS (2008)
Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
Kristian Pietras et al.
PLOS MEDICINE (2008)
Breast-cancer stromal cells with TP53 mutations and nodal metastases
Attila Patocs et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
Cedric Gaggioli et al.
NATURE CELL BIOLOGY (2007)
Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
Elisabeth M. Zeisberg et al.
CANCER RESEARCH (2007)
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Antoine E. Karnoub et al.
NATURE (2007)
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
Elisabeth M. Zeisberg et al.
NATURE MEDICINE (2007)
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinorna by k-Ras Oncogenes in adult mice
Carmen Guerra et al.
CANCER CELL (2007)
Identification of fibroblast heterogeneity in the tumor microenvironment
Hikaru Sugimoto et al.
CANCER BIOLOGY & THERAPY (2006)
Hematopoietic origin of fibroblasts/myofibroblasts: its pathophysiologic implications
Makio Ogawa et al.
BLOOD (2006)
Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas
Hanna Tuhkanen et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Decreased collagen production in chronologically aged skin - Roles of age-dependent alteration in fibroblast function and defective mechanical stimulation
J Varani et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: Phase II study results
DA Reardon et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
RN Kaplan et al.
NATURE (2005)
Distinct epigenetic changes in the stromal cells of breast cancers
M Hu et al.
NATURE GENETICS (2005)
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
A Orimo et al.
CELL (2005)
Novel antioxidant ameliorates the fibrosis and inflammation of cerulein-induced chronic pancreatitis in a mouse model
BM Yoo et al.
PANCREATOLOGY (2005)
TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
NA Bhowmick et al.
SCIENCE (2004)
Molecular characterization of the tumor microenvironment in breast cancer
M Allinen et al.
CANCER CELL (2004)
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation
E Brown et al.
NATURE MEDICINE (2003)
Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-tranplanted mice
NC Direkze et al.
STEM CELLS (2003)
A positive regulatory role for suppressor of cytokine signaling 1 in IFN-γ-induced MHC class II expression in fibroblasts
S Ilangumaran et al.
JOURNAL OF IMMUNOLOGY (2002)
Ligand-dependent genetic recombination in fibroblasts - A potentially powerful technique for investigating gene function in fibrosis
B Zheng et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
A Krtolica et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene
JM Waldburger et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2001)
Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats
R Bruck et al.
HEPATOLOGY (2001)
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