期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 375, 期 1799, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2019.0230
关键词
sleep; spindles; memory; plasticity; coupling; reactivation
类别
资金
- Canadian Research Chair in Systems Neuroscience [245716]
- CIHR Project [155957]
- NSERC [RGPIN-2018-04600]
- IRDC [108877-001]
- University of Surrey/Braithwaites foundation
- Wellcome Trust [209099/Z/17/Z]
- Wellcome Trust [209099/Z/17/Z] Funding Source: Wellcome Trust
Spindles are ubiquitous oscillations during non-rapid eye movement (NREM) sleep. A growing body of evidence points to a possible link with learning and memory, and the underlying mechanisms are now starting to be unveiled. Specifically, spindles are associated with increased dendritic activity and high intracellular calcium levels, a situation favourable to plasticity, as well as with control of spiking output by feed-forward inhibition. During spindles, thalamocortical networks become unresponsive to inputs, thus potentially preventing interference between memory-related internal information processing and extrinsic signals. At the system level, spindles are co-modulated with other major NREM oscillations, including hippocampal sharp wave-ripples (SWRs) and neocortical slow waves, both previously shown to be associated with learning and memory. The sequential occurrence of reactivation at the time of SWRs followed by neuronal plasticity-promoting spindles is a possible mechanism to explain NREM sleep-dependent consolidation of memories. This article is part of the Theo Murphy meeting issue 'Memory reactivation: replaying events past, present and future'.
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