期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 257, 期 -, 页码 132-140出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2016.08.002
关键词
Hawthorn; Fruit peels and fleshes; Polyphenol; Liver injury; High fructose
资金
- National Natural Science Foundation of China [C31171678]
- Development program for Innovative Research Team of Shaanxi Normal University, China [GK201501006]
- Science and Technology Innovation as a Whole Plan Projects of Shaanxi Province, China [2015KTCQ02-01]
Hawthorn ingestion is linked to health benefits due to the various polyphenols. The present study investigated the differential effects of polyphenols-enriched extracts from hawthorn fruit peels (HPP) and fleshes (HFP) against liver injury induced by high-fructose diet in mice. It was found that the main species of polyphenols in hawthorn was chlorogenic acid, epicatechin, rutin and hyperoside, and their contents in HPP were all higher than those in HFP. Administration of HPP was better than HFP to alleviate liver injury and hepatocyte apoptosis, reflected by the reduction of ALT, AST and ALP activities, as well as the ratio of Bax/Bcl-2 in mice. Meanwhile, HPP was also more effective than HFP to mitigate liver inflammation and oxidative stress by inhibiting inflammatory cytokine (TNF-alpha, IL-1 and IL-6) release, and elevating antioxidant enzyme activities and PPARa expression, while reducing Nrf-2 and ARE expression in mice. Interestingly, HPP-treated mice also showed the lower levels of TC, TG, LDL-C, VLDL-C and Apo-B, and the higher levels of HDL-C and Apo-A1 than HFP-treated mice via reducing FAS express. These results together with the histopathology of the liver with H&E and oil red O staining suggest that hawthorn fruit, especially its peel, is an excellent source of natural polyphenolic chemopreventive agents in the treatment of liver disorders. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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