期刊
PERIODONTOLOGY 2000
卷 83, 期 1, 页码 213-233出版社
WILEY
DOI: 10.1111/prd.12329
关键词
cancer risk; epidemiology; inflammation; missing teeth; periodontal disease; tooth loss
Epidemiologic and cancer control studies on the association of periodontal disease and cancer risk mostly suggest a positive association with overall cancer risk and certain specific types of cancer. These findings are generally consistent among cross-sectional and longitudinal studies. In this paper, we review epidemiologic studies and current knowledge on periodontal disease and cancer, with a focus on those studies conducted in the years following the Joint European Federation of Periodontology/American Academy of Periodontology Workshop on Periodontitis and Systemic Diseases in November 2012. This review also explores the role of chronic inflammation as a biologically plausible mechanistic link between periodontal disease and risk of cancer. Furthermore, it highlights studies that have examined the potential importance of certain periodontal pathogens in this association.
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