期刊
PEDIATRIC DIABETES
卷 21, 期 4, 页码 565-574出版社
WILEY-HINDAWI
DOI: 10.1111/pedi.13011
关键词
cardiometabolic risk; HOMA; NAFLD; pediatric obesity; TG; HDL
资金
- Education Department of the Government of the Basque Country [PRE_2016_1_0057, PRE_2017_2_0224, PRE_2018_2_0057, PRE_2019_2_0004]
- Spanish Ministry of Education, Culture and Sport [FPU14/03329, EST17/00210]
- Spanish Ministry of Health, Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III, Fondos de la Union Europea (FEDER), una manera de hacer Europa [PI13/01335]
- University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence
- Unit of Excellence on Exercise and Health [UCEES]
Background Non-alcoholic fatty liver disease is the most common liver disease in childhood and is related to insulin resistance and cardiometabolic risk factors. Evidence supporting the association of fitness and physical activity with hepatic fat, liver enzymes, or triglyceride-to-high-density lipoprotein ratio is scarce in children. Objective To analyze the associations of physical fitness and physical activity (PA) with percentage hepatic fat, liver enzymes, insulin resistance, and cardiometabolic risk in children with overweight/obesity. Subjects A total of 115 children (10.6 +/- 1.1 years; 54% girls) with overweight/obesity of the EFIGRO study (: NCT02258126) were included in the analyses. Methods Cardiorespiratory fitness (CRF), musculoskeletal fitness and speed-agility were measured by the Alpha-fitness tests, and PA by wGT3X-BT accelerometers. Percentage hepatic fat was assessed by magnetic resonance imaging. Alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), insulin, glucose, triglycerides (TG), and high-density lipoprotein (HDL) levels were obtained from fasting blood samples. The homeostasis model assessment insulin resistance (HOMA-IR) and AST/ALT and TG/HDL ratios were calculated. Results Higher CRF was associated with lower percentage hepatic fat (beta = -0.266, P = .01) and GGT (beta = -0.315, P < .01), and higher AST/ALT ratio (beta = 0.306, P < .01). CRF-fit children have lower GGT levels (15 +/- 1 vs 17 +/- 1 U/L, CRF-fit vs CRF-unfit children, P = .02), HOMA-IR (2.2 +/- 0.1 vs 2.9 +/- 0.1, P < .01) and TG/HDL ratio (1.4 +/- 0.1 vs 1.9 +/- 0.1, P = .01) and higher AST/ALT ratio (1.3 +/- 0.0 vs 1.2 +/- 0.0, P = .03), than CRF-unfit children. Conclusions These findings emphasize the importance of considering the improvement of CRF as a target of programs for preventing hepatic steatosis, type 2 diabetes and cardiovascular diseases in children with overweight.
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