期刊
CHEMICAL SOCIETY REVIEWS
卷 45, 期 18, 页码 5020-5054出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cs00923e
关键词
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资金
- US National Institutes of Health [GM062211]
- US National Science Foundation [CHE 14-13328]
- European Union (EU) (Cost Action - Biological Oxidation Reactions: Mechanisms and Design of New Catalysts) [CM1003]
- Scientific Research Department of Campania Region (BIP Project, POR FESR) [B25C13000290007]
- STRAIN Project, POR FSE [B25B0900000000]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1413328] Funding Source: National Science Foundation
Many efforts are being made in the design and engineering of metalloenzymes with catalytic properties fulfilling the needs of practical applications. Progress in this field has recently been accelerated by advances in computational, molecular and structural biology. This review article focuses on the recent examples of oxygen-activating metalloenzymes, developed through the strategies of de novo design, miniaturization processes and protein redesign. Considerable progress in these diverse design approaches has produced many metal-containing biocatalysts able to adopt the functions of native enzymes or even novel functions beyond those found in Nature.
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