期刊
OSTEOARTHRITIS AND CARTILAGE
卷 28, 期 7, 页码 941-952出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2020.03.006
关键词
Osteoarthritis; Bone texture analysis; Adaptive region of interest; Knee; Radiograph
资金
- National Institutes of Health, a branch of the Department of Health and Human Services [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262, AG18820, AG18832, AG18947, AG19069]
- Merck Research Laboratories
- Novartis Pharmaceuticals Corporation
- GlaxoSmithKline
- Pfizer, Inc.
- University of Oulu, Infotech Oulu
Objective: The purposes of this study were to investigate: 1) the effect of placement of region-of-interest (ROI) for texture analysis of subchondral bone in knee radiographs, and 2) the ability of several texture descriptors to distinguish between the knees with and without radiographic osteoarthritis (OA). Design: Bilateral posterior-anterior knee radiographs were analyzed from the baseline of Osteoarthritis Initiative (OAI) (9012 knee radiographs) and Multicenter Osteoarthritis Study (MOST) (3,644 knee radiographs) datasets. A fully automatic method to locate the most informative region from subchondral bone using adaptive segmentation was developed. Subsequently, we built logistic regression models to identify and compare the performances of several texture descriptors and each ROI placement method using 5-fold cross validation. Importantly, we also investigated the generalizability of our approach by training the models on OAI and testing them on MOST dataset. We used area under the receiver operating characteristic curve (ROC AUC) and average precision (AP) obtained from the precision-recall (PR) curve to compare the results. Results: We found that the adaptive ROI improves the classification performance (OA vs non-OA) over the commonly-used standard ROI (up to 9% percent increase in AUC). We also observed that, from all texture parameters, Local Binary Pattern (LBP) yielded the best performance in all settings with the best AUC of 0.840 [0.825, 0.852] and associated AP of 0.804 [0.786, 0.820]. Conclusion: Compared to the current state-of-the-art approaches, our results suggest that the proposed adaptive ROI approach in texture analysis of subchondral bone can increase the diagnostic performance for detecting the presence of radiographic OA. (c) 2020 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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