期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 24, 期 6, 页码 1149-1156出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.0c00155
关键词
raltegravir; selectivity; efficiency; API
The present work describes the development of an improved synthesis of active pharmaceutical ingredient raltegravir. The isolation of a new process intermediate and the newly developed conditions solve the issue of selectivity typical of this production process, with no need for the use of protecting groups, making the present route more efficient and sustainable than what was reported before. Efficiency comparisons with the previous processes confirm the result here obtained.
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