期刊
ORGANIC LETTERS
卷 22, 期 12, 页码 4686-4691出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01486
关键词
-
资金
- National Natural Science Foundation of China (NSFC) [21602130]
- Shanghai Jiao Tong University
A new catalyst system based on Co(OAc)(2)/bisoxazolinephosphine has been developed to catalyze the direct addition of terminal alkynes to isatins under base-free conditions. Chiral propargyl alcohols with an oxindole skeleton could be prepared in up to 99% yield and 99% ee with the help of the chiral tridentate ligand. A variety of functionalized aliphatic or aromatic alkynes and isatins were utilized in this method, and gram-scale synthesis could be achieved with 1 mol % catalyst.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据