期刊
ORGANIC LETTERS
卷 22, 期 11, 页码 4300-4305出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01339
关键词
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资金
- National Natural Science Foundation of China [21871184, 81903423, 21871284]
- Shanghai Municipal Education Commission [2019-01-07-00-10-E00072]
- Shanghai Sailing Program [19YF1449300]
- China Postdoctoral Science Foundation [2018M642064]
- Science and Technology Commission of Shanghai Municipality [18401933500]
- Chinese Academy of Sciences [XDB 20020100, QYZDY-SSW-SLH026]
An efficient one-pot synthesis of multisubstituted 9,10-dihydrophenanthrenes from easily available 2-arylazaarenes and cyclohexadienone-tethered terminal alkynes (1,6-enynes) has been successfully achieved. This domino reaction proceeded smoothly through Cp*Rh(III)-catalyzed C-H activation, direct protonation of alkenyl-Rh intermediates, intramolecular Diels-Alder reaction, alkene isomerization, subsequent ring-opening aromatization, and acetylation. This strategy was pot-economical and tolerated a wide range of functional groups. Moreover, the potent anticancer activities against HepG2 cells were observed for these artificial 9,10-dihydrophenanthrene derivatives.
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