期刊
ORGANIC LETTERS
卷 22, 期 11, 页码 4553-4556出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01615
关键词
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资金
- National Natural Science Foundation of China [21922109, 21672196, 21602001, 21831007]
- Nanjing Tech University [39837134]
- Fundamental Research Funds for the Central Universities of China [WK2060190086]
A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.
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