期刊
ORGANIC LETTERS
卷 22, 期 11, 页码 4156-4159出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01236
关键词
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资金
- Indiana University
- Joan and Marvin Carmack Fund
- Graduate Training program in Quantitative and Chemical Biology [T32 GM109825]
- National Institutes of Health [5U01GM116248]
Thioglycosides are more resistant to enzymatic hydrolysis than their O-linked counterparts, thereby becoming attractive targets for carbohydrate-based therapeutic development. We report the first development of methods for the site-selective incorporation of S-linkages into automated solution-phase oligosaccharide protocols. The protocols were shown to be compatible with the formation of S- or O-glycosides for the synthesis of mannopyranoside trimmers that incorporate both Sand O-linkages to allow the selective incorporation of an S-glycoside in various stages in an automated program.
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