期刊
ORGANIC LETTERS
卷 22, 期 10, 页码 3739-3743出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00696
关键词
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资金
- National Key RD Program [2019YFC1711500, 2018YFC1707900]
- Nature Science Foundation of Jiangsu Higher Education Institutions of China [19KJA180008]
- Jiangsu Provincial Double Creation Program (2018)
- Outstanding Scientific and Technological Innovation Team Program of Jiangsu Higher Education Institutions
- Priority Academic Program Development of Jiangsu Higher Education Institutions
A novel 6/6/5/6 tetracyclic polyketide named chartspiroton (1) was isolated from a medicinal plant endophytic Streptomyces in Dendrobium officinale. The complete structure assignment with absolute stereochemistry was elucidated through spectroscopic data, computational calculations, and single-crystal X-ray diffraction. Chartspiroton features an unprecedented naphthoquinone derivative spiro-fused with a benzofuran lactone moiety. A plausible polyketide biosynthetic pathway for 1 suggested intriguing oxidative rearrangement steps to form the five-membered lactone ring.
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