期刊
ORGANIC LETTERS
卷 22, 期 10, 页码 4006-4009出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01325
关键词
-
资金
- National Basic Research Program of China (973 Program) [2015CB856600]
- National Science Foundation of China [21971228, 21772187, 21522208]
The highly efficient copper-catalyzed enantioselective alkynylation of the remote C(sp(3))-H bond on linear primary sulfonamides is presented here using a radical relay strategy. The chiral box-copper complex, which is used to recapture the in-situ-generated alkyl radical via a 1,5-HAT strategy, is the key to success, affording the chiral alkynes after a following reductive elimination. A general substrate scope, mild conditions, and excellent regio- and enantioselective control are demonstrated in this method.
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