期刊
ORGANIC LETTERS
卷 22, 期 9, 页码 3524-3530出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00963
关键词
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资金
- NNSFC [21702027, 21971034, 21602175, 21871221]
- Fundamental Research Funds for the Central Universities [2412019FZ017]
A new type of coupling between unactivated olefins and nonstabilized alkyl radicals was achieved, which enabled the first intermolecular Heck-type reaction of cycloketone oxime esters and unactivated alkenes. This directing-group-based strategy was compatible with various unactivated alkenes and cyclobutanone-, cyclopentanone-, and cyclohexanone-derived oxime esters. Density functional theory calculations showed that both excellent regioselectivities and good diastereoselectivities could be ascribed to the 2-butanol-assisted concerted H-OBz elimination of the conformationally strained metallacyclic transition state.
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