期刊
ORGANIC LETTERS
卷 22, 期 11, 页码 4311-4315出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01358
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI) [JP16H06443, JP20H00490]
- Japan Science and Technology Agency (JST SICORP Grant) [JPMJSC1701]
The biosynthetic gene cluster of the fungal meroterpenoid emeridone F (8) was discovered in the genome of Aspergillus sp. TJ23, and its late-stage biosynthesis was elucidated by characterizing two alpha-ketoglutarate (alpha KG)-dependent dioxygenases, SptF and SptN. SptF catalyzes oxidative rearrangement followed by epoxidation, whereas SptN serves as the C-9 hydroxylase. Our study provides insight into the biosynthetic mechanisms of other andiconin (1)-derived natural products, exemplifying the important roles of alpha KG-dependent enzymes in the structural complexifications.
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