期刊
ORGANIC LETTERS
卷 22, 期 8, 页码 3302-3306出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01132
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资金
- Academia Sinica
- Ministry of Science and Technology (MOST), Taiwan [105-2113-M-001-013, 105-2628-M-001-003-MY4]
- NIH [1R35GM118056]
(-)-Aurantioclavine (1), which contains a characteristic seven-membered ring fused to an indole ring, belongs to the azepinoindole class of fungal clavine alkaloids. Here we show that starting from a 4-dimethylallyl-L-tryptophan precursor, a flavin adenine dinucleotide (FAD)-binding oxidase and a catalase-like heme-containing protein are involved in the biosynthesis of 1. The function of these two enzymes was characterized by heterologous expression, in vitro characterization, and deuterium labeling experiments.
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