期刊
ORGANIC LETTERS
卷 22, 期 8, 页码 3014-3017出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00776
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [17H06401, 19H02840, 18K14396]
- Platform Project for Supporting Drug Discovery and Life Science Research from AMED, Japan [JP19am0101092]
- Daiichi-Sankyo Award in The Society of Synthetic Organic Chemistry Japan
- SUNBOR GRANT
- Grants-in-Aid for Scientific Research [18K14396, 19H02840] Funding Source: KAKEN
A series of novel sulfur-containing cycliclipopeptides named thioamycolamides A-E, with thiazoline, thioether rings, and fatty acid moieties, were identified from the culture broth of the rare actinomycete Amycolatopsis sp. 26-4. The planar structural elucidation was accomplished by HRMS and 1D/2D NMR spectroscopic data analyses. The absolute configurations were unambiguously determined by Marfey's method, CD spectroscopy, and synthesis of partial structures. Moreover, their growth inhibitory activities against human tumor cell lines were investigated.
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