Bismuth(III)-Catalyzed Sequential Enamine-Imine Tautomerism/2-Aza-Cope Rearrangement of Stable β-Enaminophosphonates: One-Pot Synthesis of β-Aminophosphonates

A novel catalytic tautomeric transformation of a beta-enaminophosphoryl and 2-aza-Cope rearrangement sequence has been successfully applied to the one-pot synthesis of beta-aminophosphonates with high efficiency and good tolerance. In this tandem reaction, Bi(OTf)(3) exhibits unique activities and promotes both of enamine-imine tautomerism and 2-aza-Cope rearrangement.