期刊
ORGANIC LETTERS
卷 22, 期 7, 页码 2532-2536出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00293
关键词
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资金
- Zhejiang Provincial Natural Science Foundation of China [LR19B020001]
- NSFC [21772171]
- Center Chemistry for Frontier Technologies
- Fundamental Research Funds for the Central Universities [2019QNA3008]
A highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane was developed using chiral imidazole iminopyridine as a ligand to access chiral benzhydrols in good to excellent yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance. Chiral biologically active 3-substituted phthalide and (S)-neobenodine could be easily constructed through asymmetric hydroboration as a key step.
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