期刊
ORGANIC LETTERS
卷 22, 期 9, 页码 3667-3672出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01163
关键词
-
资金
- Natural Science Foundation of Zhejiang Province [LZ20B020002]
- National Natural Science Foundation of China [21672191]
A visible-light-induced remote oxyfluoroalkylation, including ketofluoroalkylation and hydroxytrifluoromethylation, of heteroalkynes is developed with dimethyl sulfoxide (DMSO) and H2O as the oxygen source, respectively. It provides a facile access to complex fluoroalkylated (Z)-alkenes in satisfactory yields with excellent regio-, stereo-, and site-selectivity. The reaction involves an uncommon vinyl radical-induced intermolecular C(sp(3))-H functionalization, thus offering a good platform for the development of remote difunctionalization of alkynes.
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