期刊
ORGANIC LETTERS
卷 22, 期 12, 页码 4653-4658出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01428
关键词
-
资金
- National Research Foundation of Korea (NRF) - Korean Government (Center for New Directions in Organic Synthesis) [NRF-2018R1D1A1A02086110, NRF-2014-011165]
We describe the asymmetric total syntheses of naphthylisoquinoline alkaloids. Atroposelective biaryl coupling reaction between naphthyl pinacol boronate and an aryl iodide, bearing (S)-2-aminopropyl group at the ortho-position using the existing central chirality as an atroposelectivity-controlling group, provided the desired biaryl product with high atroposelectivity, without the use of an external chiral source. From the resulting biaryl product, several naphthylisoquinoline alkaloids were prepared via the stereoselective formation of the isoquinoline framework with the appropriate oxidation state and stereochemistry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据