期刊
ORGANIC LETTERS
卷 22, 期 7, 页码 2720-2723出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00672
关键词
-
资金
- ERDF Project [1.1.1.5/17/A/004]
An efficient method for the synthesis of 3-hydroxymethyl isoindolinones via cobalt-catalyzed C(sp(2))-H carbonylation of phenylglycinol derivatives using picolinamide as a traceless directing group is demonstrated. The reaction proceeds in the presence of a commercially available cobalt(II) tetramethylheptanedionate catalyst and employs DIAD as a CO surrogate. This synthetic route offers a broad substrate scope, excellent regioselectivity, and full preservation of the original stereochemistry. Besides, the developed method provides a pathway for accessing valuable enantiopure 3-substituted isoindolinone derivatives.
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