Iron-Catalyzed Silylation of (Hetero)aryl Chlorides with Et3SiBpin

To date, the iron-catalyzed construction of C-heteroatom bonds has been less developed due to the difficulty of transmetalation with heteroatom anions and the sluggish reductive elimination. Herein we report an iron-catalyzed method for the silylation of (hetero)aromatic chlorides. It features high efficiency, a broad substrate scope, and excellent functional group compatibility. Moreover, this protocol enables the late-stage silylation of some pharmaceuticals, thus providing an excellent method to access valuable intermediates in medicinal chemistry.