期刊
OPTICS EXPRESS
卷 28, 期 11, 页码 15783-15793出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.391889
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资金
- National Natural Science Foundation of China [61705083, U1701268, 61805106]
- Natural Science Foundation of Guangdong Province [2019A1515011144, 2018A030313677]
- Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme [2019BT02X105]
- Fundamental Research Funds for the Central Universities [21617305]
Fiber-optic biosensors are of great interest to many bio/chemical sensing applications. In this study, we demonstrate a high-order-diffraction long period grating (HOD-LPG) for the detection of prostate specific antigen (PSA). A HOD-LPG with a period number of less than ten and an elongated grating pitch could realize a temperature-insensitive and bending-independent biosensor. The bio-functionalized HOD-LPG was capable of detecting PSA in phosphate buffered saline with concentrations ranging from 5 to 500 ng/ml and exhibited excellent specificity. A limit of detection of 9.9 ng/ml was achieved, which is promising for analysis of the prostate specific antigen. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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