期刊
ACTA PHARMACOLOGICA SINICA
卷 36, 期 10, 页码 1219-1227出版社
ACTA PHARMACOLOGICA SINICA
DOI: 10.1038/aps.2015.92
关键词
cancer cells; intra-tumor heterogeneity; genetic heterogeneity; signal transduction; cancer therapy
资金
- China Ministry of Science and Technology Key New Drug Creation and Manufacturing Program [2013ZX09102015, 2014ZX09102001002]
- China Ministry of Science and Technology Research [2013ZX10002010-009]
- National Natural Science Foundation of China [81302792, 81373447, 91413121, 91213304]
- China National Key Basic Research Program [2012CB910704, 2013CB910900]
Recent studies have revealed extensive genetic and non-genetic variation across different geographical regions of a tumor or throughout different stages of tumor progression, which is referred to as intra-tumor heterogeneity. Several causes contribute to this phenomenon, including genomic instability, epigenetic alteration, plastic gene expression, signal transduction, and microenvironmental differences. These variables may affect key signaling pathways that regulate cancer cell growth, drive phenotypic diversity, and pose challenges to cancer treatment. Understanding the mechanisms underlying this heterogeneity will support the development of effective therapeutic strategies.
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