期刊
CHEMICAL REVIEWS
卷 116, 期 14, 页码 7818-7853出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.6b00024
关键词
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资金
- National Institutes of Health [1R01GM085322]
- Northwestern University
- BBSRC
- Royal Society of Chemistry
The prodiginine family of bacterial alkaloids is a diverse set of heterocyclic natural products that have likely been known to man since antiquity. In more recent times, these alkaloids have been discovered to span a wide range of chemical structures that possess a number of interesting biological activities. This review provides a comprehensive overview of research undertaken toward the isolation and structural elucidation of the prodiginine family of natural products. Additionally, research toward chemical synthesis of the prodiginine alkaloids over the last several decades is extensively reviewed. Finally, the current, evidence-based understanding of the various biosynthetic pathways employed by bacteria to produce prodiginine alkaloids is summarized.
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