期刊
OBESITY SURGERY
卷 30, 期 9, 页码 3549-3560出版社
SPRINGER
DOI: 10.1007/s11695-020-04710-1
关键词
Bariatric surgery; Endothelial dysfunction; MCP-1; ICAM-1; E-selectin; VCAM-1
类别
Background This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. Methods PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies. Results A total of 29 different studies were included. BS reduced the concentrations of MCP-1 (weighted mean difference (WMD) = - 58.91; 95%CI (confidence interval), - 77.10 to - 40.72;P = < 0.001), ICAM-1 (WMD = - 36.58; 95%CI, - 49.65 to - 23.52;P = < 0.001), and E-selectin (WMD = - 11.22; 95%CI, - 14.43 to - 8.01;P < 0.001), but had no significant effect on VCAM-1. Conclusion Bariatric surgery reduces circulating concentration of MCP-1, ICAM-1, and E-selectin, but not VCAM-1.
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