期刊
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
卷 30, 期 9, 页码 1500-1511出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.numecd.2020.05.001
关键词
Metabolome; Microbiome; Soy; Nutrition; Blood pressure; Cardiometabolic health
资金
- AHA Scientist Development Grant [15SDG24890015]
- P&F Award from the Vanderbilt University Medical Center's Digestive Disease Research Center
- NIH [P30DK058404, DK095913]
- Data Science Initiative Award by the University of Wisconsin-Madison Office of the Chancellor
- Wisconsin Alumni Research Foundation
- [R01DK117144]
- [R01HL142856]
Background and aims: Consumption of soy foods has been associated with protection against cardiometabolic disease, but the mechanisms are incompletely understood. We hypothesized that habitual soy food consumption associates with gut microbiome composition, metabolite production, and the interaction between diet, microbiota and metabolites. Methods and results: We analyzed dietary soy intake, plasma and stool metabolites, and gut microbiome data from two independent cross-sectional samples of healthy US individuals (N = 75 lean or overweight, and N = 29 obese). Habitual soy intake associated with several circulating metabolites. There was a significant interaction between soy intake and gut microbiome composition, as defined by gut enterotype, on metabolites in plasma and stool. Soy consumption associated with reduced systolic blood pressure, but only in a subset of individuals defined by their gut microbiome enterotype, suggesting that responsiveness to soy may be dependent on microbiome composition. Soy intake was associated with differences in specific microbial taxa, including two taxa mapping to genus Dialister and Prevotella which appeared to be suppressed by high soy intake We identified context-dependent effects of these taxa, where presence of Prevotella was associated with higher blood pressure and a worse cardiometabolic profile, but only in the absence of Dialister. Conclusions: The gut microbiome is an important intermediate in the interplay between dietary soy intake and systemic metabolism. Consumption of soy foods may shape the microbiome by suppressing specific taxa, and may protect against hypertension only in individuals with soy-responsive microbiota. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
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