期刊
CHEMICAL RESEARCH IN TOXICOLOGY
卷 29, 期 5, 页码 823-833出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrestox.6b00001
关键词
-
资金
- Hong Kong Research Grant Council grant [17111715]
Contamination of food/feedstuffs by mycotoxins is a serious problem worldwide, causing severe economic losses and serious health problems in animals/humans. Deoxynivalenol (DON) is a major mycotoxin contaminant and is known to impair intestinal barrier function Grapes and red wine are rich in polyphenols, such as resveratrol (RES), which has striking antioxidant and anti-inflammatory activities. RES is a food-derived component; therefore, it may be simultaneously present with DON in the gastrointestinal tract. The aim of this study was to explore - in, vitro protective effects of RES against DON-induced intestinal damage. The, results showed that RES could protect DON-induced bacteria translocation because of enhanced of intestinal barrier function - I I by restoring the DON-induced,decrease in transepithelial electrical resistance and increase in paracellular permeability. Further mechanistic studies demonstrated that RES protects against DON-induced barrier dysfunction by promoting the assembly of claudin-4 in the tight junction complex. This is probably mediated through modulation of IL-6 and IL-8 secretion via mitogen activated protein kinase-dependent pathways. Our results imply that RES can protect against DON-induced intestinal damage and: that RES may be used as a novel dietary intervention strategy to reduce DON toxicity in animals/humans.
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