期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 39, 期 7, 页码 1020-1035出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2020.1740929
关键词
DNA binding; L-Dopa; layered double hydroxide; magnetic nanocarrier
资金
- Razi University of Kermanshah, Iran
The principal goal of this study is to evaluate the interaction of Fe3O4@CaAl-LDH@L-Dopa and Fe3O4@CaAl-LDH nanoparticles with calf thymus DNA. The magnetic nanoparticles were previously prepared by a chemical co-precipitation method, and the surface of the Fe3O4 nanoparticles was coated with CaAl layered double hydroxides. The antiparkinsonian drug L-Dopa was carried by this core-shell nanostructure to achieve the drug delivery system with suitable properties for biological applications. Also, the interaction of Fe3O4@CaAl-LDH@L-Dopa and Fe3O4@CaAl-LDH nanoparticles with CT-DNA was studied using, UV-Visible spectroscopy, viscosity, circular dichroism (CD), and fluorescence spectroscopy techniques. The results of investigations demonstrated that Fe3O4@CaAl-LDH@L-Dopa and Fe3O4@CaAl-LDH nanoparticles have interacted via minor groove binding and intercalated to CT-DNA, respectively.
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