Incidence and risk factors of proximal junctional kyphosis after internal fixation for adult spinal deformity: a systematic evaluation and meta-analysis

To investigate the factors associated with proximal junctional kyphosis (PJK). A systematic search was performed. The weighted mean difference (WMD) was pooled for continuous variables, and the odds ratio (OR) was calculated for dichotomous variables. The PJK group had higher values for age (WMD = 2.53, 95%CI = 1.38 similar to 3.68, P < 0.001), female gender (OR = 1.56, 95%CI = 1.29 similar to 1.87, P < 0.001), and diagnosed osteoporosis (OR = 1.58, 95%CI = 1.11 similar to 2.26, P = 0.01). Preoperatively, significant differences were detected in sagittal vertical axis (SVA) (WMD = 19.29, 95%CI = 16.60 similar to 21.98, P < 0.001), pelvic incidence minus lumbar lordosis (PI-LL) (WMD = 2.71, 95%CI = 0.25 similar to 5.18, P = 0.03), pelvic tilt (PT) (WMD = 2.64, 95%CI = 1.38 similar to 3.90, P < 0.001), lumbar lordosis (LL) (WMD = - 1.76, 95%CI = - 2.73 similar to -0.79, P < 0.001), and sacral slope (SS) (WMD = - 2.80, 95%CI = - 5.57 similar to -0.04, P = 0.001). At follow-up, the following were higher in the PJK group: thoracic kyphosis (TK) (WMD = 5.51, 95%CI = 2.23 similar to 8.80, P < 0.001), proximal junctional angle (PJA) (WMD = 9.07, 95%CI = 4.21 similar to 13.92, P < 0.001), and PT (WMD = 1.51, 95%CI = 0.31 similar to 2.72, P = 0.01). However, there was no significant difference in SS (P = 0.49), and SVA (P = 0.11) between groups. Fusion to S1 or pelvis significantly increased the risk of PJK (OR = 2.08, P < 0.001). Ligament augmentation reduced the risk of PJK (OR = 0.34, 95%CI = 0.21 similar to 0.53, P < 0.001) better than the use of laminar hook (OR = 0.46, P < 0.001). Although no difference was detected for preoperative SRS-22 score (P = 0.056), a lower score (WMD = - 0.24, 95%CI = - 0.35 similar to -0.14, P < 0.001) was detected in PJK group at follow-up. The elderly female ASD patients were more susceptible to PJK, especially for those with osteoporosis, high preoperative SVA, low LL, large PT, and LIV extended to pelvis. The use of laminar hook and ligament reinforcement at the proximal end might prevent PJK.

Automated summary

The study found that factors such as age, female gender, osteoporosis, preoperative SVA, LL, and large PT were positively associated with proximal junctional kyphosis (PJK), while fusion to S1 or pelvis increased the risk of PJK. Sagittal plane and postoperative thoracic kyphosis, proximal junctional angle were also related to PJK.