期刊
NEUROSCIENCE RESEARCH
卷 159, 期 -, 页码 25-33出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2020.04.007
关键词
PINK1; Parkin; Ubiquitin; Mitophagy; MAMs; Mitochondria; Parkinson
资金
- Cariplo project [2017-0575]
- Italian Ministry of Healthy (Ricerca Corrente 2020, Ricerca di Rete progetto ParkNet)
In 2004, PINK1 was established as a gene linked to early onset of autosomal recessive juvenile Parkinsonism. Since then, tremendous efforts allowed involving the gene product in diverse events but with a strong focus on its partnership with the protein Parkin for the degradation of damaged mitochondria through mitophagy. Yet, it is now clear that the importance of PINK1 encompasses a wider spectrum of intracellular processes. In this minireview, we highlight some of the PINK1 interplays and recent advances, including its growing involvement in immunity and also its emerging place in this era of mitochondria-organelles contact sites. (C) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据