期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 112, 期 -, 页码 345-352出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2020.02.017
关键词
Twin study designs; Depression; DNA methylation; Epigenetics
资金
- Spanish Ministry of Economy and Competitivity (ES-EUEpiBrain project) [SAF2015-71526-REDT]
- Instituto de Salud Carlos III [PI15/00097]
- Fondo Europeo de Desarrollo Regional Una manera de hacer Europa (FEDER)
- Biomedical Research Networking Center for Mental Health (CIBERSAM) [SAM15PI12]
- Comissionat per a Universitats i Recerca del DIUE
- Generalitat de Catalunya [2017SGR1577]
- NARSAD Distinguished Investigator Grant
Monozygotic (MZ) twin studies constitute a key resource for the dissection of environmental and biological risk factors for human complex disorders. Given that epigenetic differences accumulate throughout the lifespan, the assessment of MZ twin pairs discordant for depression offers a genetically informative design to explore DNA methylation while accounting for the typical confounders of the field, shared by co-twins of a pair. In this review, we systematically evaluate all twin studies published to date assessing DNA methylation in association with depressive phenotypes. However, difficulty to recruit large numbers of MZ twin pairs fails to provide enough sample size to develop genome-wide approaches. Alternatively, region and pathway analysis revealed an enrichment for nervous system related functions; likewise, evidence supports an accumulation of methylation variability in affected subjects when compared to their co-twins. Nevertheless, longitudinal studies incorporating known risk factors for depression such as childhood trauma are required for understanding the role that DNA methylation plays in the etiology of depression.
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